Control of mitochondrial permeability by Bcl-2 family members
نویسندگان
چکیده
منابع مشابه
Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.
Mitochondria participate in apoptosis through a range of mechanisms that vary between vertebrates and invertebrates. In vertebrates, they release intermembrane space proteins, such as cytochrome c, to promote caspase activation in the cytosol. This process is the result of the loss of integrity of the outer mitochondrial membrane caused by proapoptotic members of the Bcl-2 family. This event is...
متن کاملControl of mitochondrial apoptosis by the Bcl-2 family.
Programmed cell death, or apoptosis, is important for the development and homeostasis of tissues. Too little cell death can result in autoimmune diseases or cancer, whereas excessive cell death can lead to debilitating degenerative diseases of the heart or nervous system. The realization that apoptosis was genetically controlled first arose when it was observed that certain mutants of the model...
متن کاملRole of Bcl-2 in Apoptosis and Mitochondrial Permeability
Apoptosis is of great importance in various biological systems for functioning of physiological processes in multicellular organisms. It is also required for normal functioning of the body, embryonic development , tissue homeostasis , functioning of immune system , removal of defective cells. Various factors take part in the process of apoptosis , the critical control point being regulated by t...
متن کاملThe autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis.
Autophagy and apoptosis constitute important determinants of cell fate and engage in a complex interplay in both physiological and pathological settings. The molecular basis of this crosstalk is poorly understood and relies, in part, on "dual-function" proteins that operate in both processes. Here, we identify the essential autophagy protein Atg12 as a positive mediator of mitochondrial apoptos...
متن کاملBcl-2 family members: dual regulators of apoptosis and autophagy.
The essential autophagy protein and haplo-insufficient tumor suppressor, Beclin 1, interacts with several cofactors (Ambra1, Bif-1, UVRAG) to activate the lipid kinase Vps34, thereby inducing autophagy. In normal conditions, Beclin 1 is bound to and inhibited by Bcl-2 or the Bcl-2 homolog Bcl-X(L). This interaction involves a Bcl-2 homology 3 (BH3) domain in Beclin 1 and the BH3 binding groove ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2004
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2003.10.016